In the world of cell culture, the substrate matters. For many anchorage-dependent cells, simply providing a surface isn’t enough. These cells need biological cues that replicate the natural environment of the body to adhere and grow properly.  That’s why surface coating of the substrate plays a vital role in the in vitro cell culture for biomimicry in vivo conditions.

When working with gas-tight NanoFil™ syringes, especially in applications involving viral vectors or delicate biological samples, priming your syringe correctly is essential to ensure reliable and accurate sample delivery. Even microscopic air pockets can lead to inconsistent dosing or air injection, which can be detrimental in high-precision workflows. Here's a step-by-step guide to priming your NanoFil™ syringe system effectively.

In any successful cell culture experiment, the story starts at the surface. Whether you're working with primary neurons, stem cells, or epithelial monolayers, anchorage-dependent cells rely on the substrate beneath them to survive, adhere, and thrive. The chemical and biological cues provided by the surface can dramatically influence cell morphology, proliferation, differentiation, and even gene expression.

That’s why surface coatings on cell culture dishes plays a critical role in mammalian cell culture-based research. From naturally derived proteins like collagen, fibronectin, and vitronectin to synthetic compounds such as poly-D-lysine (PDL) and poly-L-lysine (PLL), these treatments transform plain cultureware into biologically active environments. The right coating not only supports attachment, but it can help to maintain normal cellular morphology and guide the cell fate. Anchorage dependent cells, when unable to find appropriate surface to adhere to, can undergo programmed or unprogrammed cell death.  

At WPI, we apply these specialized surface treatments to our FluoroDish™ glass-bottom culture dishes which are designed for high-quality imaging and precision cell work.

At WPI, we know precision and ease of use matter, especially when you're handling microinjections at the smallest scales. That’s why we’ve created a quick unboxing and setup guide to help you hit the ground running with your new NanoFil™ gas-tight syringe system.

Whether you're new to NanoFil™ or just want a refresher on what's included and how to get started, this article walks you through everything you need to know.

In barrier model research, the integrity of your cell monolayers isn’t just important—it’s everything. Whether you're studying epithelial transport, drug permeability, or disease modeling, your ability to trust your data hinges on the health of your cultures. That’s why so many researchers rely on Transendothelial/Transepithelial Electrical Resistance (TEER) as a simple, non-invasive, real-time quantitative evaluation of the integrity of your cellular barrier.

Transepithelial/Transendothelial Electrical Resistance (TEER) is a widely used quantitative technique to assess the integrity of tight junctions in cell monolayers. WPI’s EVOM™ is the gold standard for TEER measurement and is particularly valuable in studies involving drug transport, toxicology, inflammation, and organ-on-chip systems. TEER measurement provides fast and quantitative data and can be used as an efficient and cost-effective method for drug discovery and development.  There are certain biological and technical factors that are known to affect TEER readings. This article reviews the key variables that influence TEER outcomes in cell culture studies and how to ensure consistent TEER measurement analysis can be done by minimizing or eliminating the effects of these factors.

Whether you're conducting patch-clamp recordings, microinjections, or other high-precision tasks under a microscope, the right micromanipulator can make all the difference. At WPI, we offer a full range of manual and motorized micromanipulators designed to support both routine lab work and complex experimental setups. But which one is the best fit for your needs? Here’s a closer look at the key differences, features, and benefits of each.

WPI’s NanoFil™ Gas-Tight syringe offers the ultimate precision for sensitive tissue, particularly for ophthalmic-specific applications. The injection system boasts zero dead volume in the terminal between the interchangeable needle and plunger— creating a truly gas-tight system once primed. NanoFil™ needles are offered in blunt or beveled styles down to 36G, the smallest commercially available gauge on the market.

In traditional hanging-insert workflows, media changes are a slow, manual bottleneck. Researchers must lift each insert—often with tweezers—to access the narrow gap between insert and well for pipetting or aspiration. This labor-intensive step not only adds time and variability but also risks disturbing delicate cellular layers. Now, WPI’s 24-Well Auto Exchange Cell Culture Plate fundamentally reshapes this workflow by combining smart well geometry, integrated fluidics, and robust insert seating to enable fully automated, multichannel TEER measurement on the EVOM™ Auto—and to simplify every step of media exchange and sampling, whether done by hand or robot. It enables seamless media exchange and multichannel TEER measurements without ever lifting an insert.

Precision and control are vital in ophthalmic procedures, and having the right surgical scissors makes all the difference. WPI offers a large variety of high-performance scissors specifically suited for the demands of eye surgery and laboratory microdissection work. Here's a quick guide to some of the most commonly used types of ophthalmic scissors.

Whether you're culturing bacteria, working with stem cells, or imaging live cells or embryos, attention to detail with Petri dishes can make or break your results. Use this quick checklist to avoid common mistakes and maintain best practices in the lab.

If you’ve ever stepped into a research lab, you know it’s filled with specialized tools and equipment—all essential for keeping experiments running smoothly. When people ask “What are laboratory supplies” the short answer is: they’re the essentials that help scientists and researchers get their work done. That includes everything from basic items like petri dishes and pipettes to more advanced laboratory equipment like microscopes and micromanipulators.

GxP is a critical framework for research laboratories, ensuring data integrity, product safety, regulatory compliance, and operational efficiency. By adhering to these guidelines, laboratories can produce reliable research, protect public health, and maintain the highest standards of scientific and ethical responsibility. By streamlining compliance reporting and simplifying audit preparation with GxP compliant software, organizations can avoid delays, reduce the risk of non-compliance penalties, and demonstrate a commitment to regulatory adherence with confidence.

The ultimate aim of GxP (Good “X” Practices) is to ensure patient safety by maintaining the highest standards of quality, integrity, and compliance throughout the production and research process. In highly regulated industries, adhering to GxP guidelines not only guarantees the safety and efficacy of products but also enhances operational efficiency and supports global market access. By automating compliance processes like monitoring, reporting, and training, GxP compliance software reduces manual workloads, improves productivity, and bolsters organizational credibility, ensuring a streamlined and compliant approach to research and development.

With the incredible variety of designs, including the style, tip shape, size, and construction material, it can be daunting to select the ideal surgical forceps for a specific application. Surgical forceps are essential tools in laboratory applications, particularly in medical, biological, and pharmaceutical research. By choosing the appropriate instrument, you ensure your precision, efficiency, and safety. Consider the factors when you are selecting surgical forceps for laboratory applications.

In the competitive world of pharmaceuticals, biotechnology, and other regulated industries, compliance with GxP (Good “X” Practices) is vital not only for ensuring safety and quality but also for improving operational efficiency and enhancing organizational credibility and supports access to global markets.

In industries like pharmaceuticals and biotechnology, where regulatory compliance is critical, adhering to GxP (Good “X” Practices) is essential to ensuring product safety, quality, and efficacy. Non-compliance with these standards can lead to severe consequences, including product recalls, legal liabilities, and a tarnished brand reputation. In this article we look at the benefits of GxP for reducing risks and facilitating audits and inspections.

In regulated industries such as pharmaceuticals, biotechnology, and medical research, managing vast amounts of documentation is a crucial aspect of compliance. Regulatory agencies require organizations to maintain accurate, verifiable records of their processes, from standard operating procedures (SOPs) to testing data and batch records. However, manual documentation can be prone to errors, inefficiencies, and compliance risks. GxP compliant software provides a solution by centralizing document management, enforcing structured workflows, and ensuring data integrity. By streamlining documentation processes, GxP compliance tools help organizations maintain organized, audit-ready records while improving efficiency and reliability in scientific research.

Over the past century, hand-held surgical instruments have undergone significant advancements in materials, design, and functionality. These instruments, which are designed for cutting, clamping, grasping, and retracting tissue, have developed to improve surgical precision, minimize trauma, and enhance patient outcomes. The transformation of surgical instruments has morphed basic stainless steel tools into highly specialized, ergonomic, and disposable devices designed for specific procedures.

In regulated industries such as pharmaceuticals, biotechnology, and clinical research, adherence to GxP (Good "X" Practice) guidelines is essential to maintaining quality, safety, and compliance. These regulations ensure that research findings, manufacturing processes, and clinical trials meet rigorous standards set by regulatory agencies worldwide. Without proper compliance, organizations risk facing legal consequences, financial losses, and reputational damage. Implementing GxP compliance software and specialized laboratory equipment is a critical step in helping laboratories streamline processes, maintain accurate records, and uphold data integrity. This article explores how GxP guarantees regulatory compliance and ensures data integrity, two fundamental aspects of high-quality scientific research and product development.

Organoids are three-dimensional, miniature models of organs and tissues that are grown in vitro from stem cells or other progenitor cells with the ability to differentiate into a cell type found in a given organ or tissue. They closely mimic the structure and function of human organs, making them valuable tools for studying human development, disease modeling, drug discovery, and personalized medicine.

When you are looking for a low toxicity adhesive with some elasticity and good moisture resistance, choose a silicone adhesive.