Let’s take a look at how to set up a Digital Rat/Mouse, Neonatal Rat Stereotaxic frame. In a few steps you will be up and running.

Transepithelial/transendothelial electrical resistance (TEER) measurement is one of the most used practices to evaluate cellular health, such as cellular confluence, barrier integrity, or barrier function of cellular monolayers grown onto multiwells. The TEER measurement using WPI’s Epithelial Voltohmmeter (EVOM) is considered the gold standard because of its reliable measurements and numerous literature citations using various cell types. The EVOM™ Manual and EVOM™ Auto along with different choices of electrodes (STX4, STX HTS high throughput screening, EndOhm chambers, and multielectrode array for EVOM™ Auto) allow researchers to perform and analyze cell samples in 6, 12, and 24 removable inserts and 24 and 96 HTS multiwell plate formats. The major challenges researchers may encounter while performing studies to capture TEER measurement include:
·      Unstable read outs
·      Out of range values 
·      Inconsistent measurements among sample replicates or batches.
Consider the following factors to overcome any TEER measurement problems and obtain accurate and reliable measurements. 

Transepithelial Electrical Resistance (TEER) is a widely used technique in the life sciences fields and therapeutic development. It measures the electrical resistance across a cell monolayer, providing information about the integrity and functionality of epithelial barriers. TEER has proven to be a valuable tool in various fields, including drug absorption studies, tissue engineering, and disease modeling. This article aims to explore the benefits of TEER and its applications in different research areas.

EVOM™ Auto High Throughput (HTS) Transepithiel Electrical Resistance (TEER) Measurement System with 24 and 96 transwell capability can switch between different 24 and 96 HTS well plates by using matching electrode arrays and plate positioners. Here we demonstrate how to switch to a 24 transwell plate after using a 96 transwell plate. 

EVOM™ Auto is WPI’s latest high throughput screening TEER measurement system with 24 and 96 HTS transwell plate measurement capability, and it offers easy options for switching between different plates. I will show you how to setup it up. The Interface Unit is the controller that establishes communication between the EVOM™ Auto software and the autosampler. 

EVOM™ Auto High Throughput (HTS) Transepithiel Electrical Resistance (TEER) Measurement System with 24 and 96 transwell capability can switch between different 24 and 96 HTS transwell plates by using matching electrode arrays and plate positioner. Here we demonstrate how to install a well plate. 

The EVOM™ Auto High Throughput (HTS) Transepithiel Electrical Resistance (TEER) Measurement System with 24 and 96 transwell capability has a removable electrode array head. Different electrode arrays can be used with the same system to analyze a variety of 24 and 96 transwell HTS plates. 

EVOM™ Auto High Throughput (HTS) Transepithiel Electrical Resistance (TEER) Measurement System with 24 and 96 transwell capability can switch between different 24 and 96 HTS well plates by using matching electrode arrays and plate positioners. Here we demonstrate how to switch to a 24 transwell plate after using a 96 transwell plate. 

 Micromanipulators  are an important tool used to execute minute, fine-tuned movements critical for various applications including microinjection into cells or tissue, microscopy, as well as for research involving biological and nano-engineering implementation. Before selecting a micromanipulator, consider the following to choose the best option for your application:

Hemostatic forceps, also called ring forceps or hemostats, are common surgical instruments used in medical, veterinary, and laboratory settings to control bleeding during procedures. Hemostats are used to clamp blood vessels, tissues, or other small structures, effectively minimizing blood flow during surgical procedures. Hemostats prevent excessive bleeding for the subject and offer a clear view of the surgical site for the operator. Here’s a brief introduction to the features and uses of hemostatic forceps in a laboratory setting.

Cleaning laboratory syringes helps prevent contamination and ensures accurate dosing. You should always adhere to the protocols of your institution and the manufacturer of your syringe. Specific cleaning requirements may vary based on the intended use of the syringe, its material composition , and the sample fluid introduced. Here is a typical protocol for cleaning a laboratory syringe.

Laboratory syringes are used for accurate measurement and administration of fluids in medical, laboratory, and industrial settings. Proper maintenance is crucial to ensure their functionality and accuracy. Here we will examine some common maintenance issues you may encounter with your reusable laboratory syringes.

The EVOM™ family of TEER measurement meters have been cited in over 16,000 peer-reviewed, scientific journal articles. The EVOM™ Manual has been designed to improve workflow efficiency, increase stability, and provide more repeatable measurements than older Trans Epithelial Electrical Resistance (TEER) meters including the Millipore MilliCell® ERS-2, Millipore MilliCell ERS and World Precision Instruments EVOM2, EVOM and EVOMX. Here’s a quick summary of benefits of the EVOM™ Manual versus the MilliCell ERS voltohmmeter.

Choosing the right syringe type depends on the specific application and the requirements of your task. Syringes come in various sizes, materials, and designs, each suited for different purposes. Here are some factors to consider when selecting a syringe type.

Deciding which syringe pump is best for your application involves factors like the flow rate, number of channels, and precision that you require to select and appropriate system. Use a syringe pump when manual syringe handling will negatively impact the delivery of your sample, and to precisely regulate the rate of fluid dispensed from a syringe. These pumps are utilized in diverse areas, including biomedical or chemical applications, general research, healthcare, and in industrial settings. Below is a guide to assist in deciding which syringe pump is most suitable for you:

On December 29, 2022, the FDA Modernization Act 2.0 was signed into law, which allows alternatives to animal testing for new drug development. This has opened the door for new pathways to drug discovery and development that involve Artificial Intelligence, cell culture-based assays, and organ-on-chip applications. It also moved the field closer to the three Rs of animal testing:

WPI’s FluoroDish™ cell culture dishes are optimally designed for a wide variety of cell culture and embryology experiments including high resolution imaging, live cell imaging, electrophysiological recordings of fluorescently tagged cells, and microinjection.  FluoroDish™ cell culture dishes are far better than standard petri dishes, because they are designed with optical quality glass bottoms, which offer superior imaging using the latest microscopy technology. WPI’s FluoroDishes™ have been cited in over 550 peer-reviewed publications by cell culture laboratories across the world.

Building a custom surgical instrument kit gives you the flexibility, precision, and control you need to advance medical knowledge, improve patient outcomes, and push the boundaries of surgical science.