Why NanoFil™ Microsyringes are Ideal for Intravitreal Injections
WPI’s NanoFil™ Gas-Tight syringe offers the ultimate precision for sensitive tissue, particularly for ophthalmic-specific applications. The injection system boasts zero dead volume in the terminal between the interchangeable needle and plunger— creating a truly gas-tight system once primed. NanoFil™ needles are offered in blunt or beveled styles down to 36G, the smallest commercially available gauge on the market.
Benefits: Intravitreal Injections
WPI’s beveled NanoFil™ needles offer a tri-bevel tip, which enhances ease of entry into tissue while reducing mechanical damage. Unlike a single-bevel needle which can resist entry, the tri-bevel offers superior sharpness, critical for working with tissues sensitive to tearing and general mechanical damage.
Application Kits
| When holding a syringe for injections becomes cumbersome, WPI offers two handheld kits: blunt tipped – RPE (retinal pigment epithelium) and beveled tipped – IO (intraocular) kits. These kits easily mate to the NanoFil™ for a lightweight solution for handheld manipulation. Paired with WPI’s UMP3 syringe pump, low-volume injections can easily be controlled. Likewise, if glass tips are preferred, WPI’s NANOLITER2020 can be considered as an alternative. |
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Discover the Difference NanoFil™ Can Make
| For researchers conducting delicate ophthalmic procedures, WPI’s NanoFil™ Microsyringe system delivers unmatched precision and minimal tissue disruption. Whether you’re performing intravitreal injections or working with other sensitive tissues, NanoFil’s zero dead volume and ultra-fine needles set a new standard for microinjection accuracy. |
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References
- Haldrup, S.H., Fabian-Jessing, B.K., Jakobsen, T.S., Lindholm, A.B., Adsersen, R.L., Aagaard, L., Bek, T., Askou, A.L., & Corydon, T.J. (2024). Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model. Molecular Therapy: Methods & Clinical Development. https://doi.org/10.1016/j.omtm.2024.101242
- Romanovsky, D., Scherk, H., Föhr, B., Babutzka, S., Bogedein, J., Lu, Y., Reschigna, A., & Michalakis, S. (2025). Heparan sulfate proteoglycan affinity of adeno-associated virus vectors: Implications for retinal gene delivery. European Journal of Pharmaceutical Sciences, 206. https://doi.org/10.1016/j.ejps.2025.107012
- Taylor, B.E., Howell, S.J., Lee, C., Taylor, Z., Barber, K., & Taylor, P.R. (2025). Diabetes- mediated STEAP4 enhances retinal oxidative stress and impacts the development of diabetic retinopathy. Antioxidants, 14(205). https://doi.org/10.3390/antiox14020205
- Zeng, Y., Qian, H., Wu, Z., Marangoni, D., Sieving, P. A., & Bush, R. A. (2019). AAVrh-10 transduces outer retinal cells in rodents and rabbits following intravitreal administration. Gene therapy, 26(9), 386–398. https://doi.org/10.1038/s41434-019-0094-3
