GxP is a collective term for various quality and regulatory practices that ensure the integrity, reliability, and quality of data, products, and processes in regulated industries, including pharmaceuticals, biotechnology, and medical research. 

The EVOM™ Auto with GxP module allows you to synchronize the date and time of the EVOM™ Auto system to the computer. This date is used to time stamp data when acquiring data and when staging it for export.

The adhesive you select will depend largely on your biomedical research laboratory application. If you are building electrodes, you might use a silver-filled, conductive epoxy to connect a Ag/AgCl pellet. For instantaneous bonding when mounting a rodent brain slice, you might select an ethyl cyanoacrylate. When you are looking for a low toxicity adhesive with some elasticity and good moisture resistance, a silicone adhesive is the option of choice. When used with living tissue, an adhesive must be:

EVOM™ GxP compliance Module is 21 CFR Part 11 compliant software that meets the FDA's requirements for electronic records and signatures. When running the EVOM™ Auto with the GxP.

Cyanoacrylate adhesives have been on the market since 1958. Most industrial or household grade cyanoacrylate (like Super Glue) are made of shorter alkyl chain derivatives such as methyl or ethyl cyanoacrylate (WPI #7341 and #7342). They are very useful for temporarily holding tissues such as mounting specimens for microtome sectioning. A family of adhesives containing octyl cyanoacrylate, a plasticizer and stabilizer, was developed In the 1990's (one of them approved by FDA for human use). When bonding to tissue, these new adhesives are four times stronger and less toxic than butyl cyanoacrylate. Compared with the traditional suture, the new super adhesive has several advantages. Cyanoacrylates Not Suitable for Live Animals.

Sylgard is a 2-part silicone elastomer with a very low dielectric constant, which makes it ideal for patch clamping and many other lab applications, especially in electrophysiology. The twin pack is a convenient, single use sleeve containing both parts of the adhesive. We will show you how to properly mix the Sylgard Twin Pack.

EVOM™ Auto is a high throughput screening (HTS) platform offering fast, non-invasive sample scanning by comparing electrical resistance measurements (transepithelial/transendothelial electrical resistance: TEER). TEER measurement experiments are simple to set up and less time consuming than more complex molecular studies. The GxP module offers 21 CFR Part 11 compliant software that is required by the FDA. In this video, we will see how to delete an EVOM™ Auto GxP measurement sequence you no longer need.

Both Kwik-Sil and Kwik-Cast are silicone adhesives, but they are a little different.

WPI’s EVOM™ line of transepithelial electrical resistance (TEER) measurement systems use silver-silver chloride electrodes for taking measurements. Our newest automated TEER measurement unit, the EVOM™ Auto, is available with an optional GxP module to ensure 21 CFR Part 11 compliance. GxP represents the quality guidelines in place to ensure standards are met. It is used for protocols like Good Laboratory Practice, Good Pharmaceutical Practice, Good Clinical Practice, Good Manufacturing Practice, and Good Research Practice.

Regular maintenance keeps your EVOM™ Auto GxP electrodes performing optimally. Periodically, you will need to re-chloride your electrodes. Just follow the steps shown in this video.

EVOM™ Auto with GxP powered by TotalLab automates your TEER measurements with the confidence that your data security complies with FDA’s 21 CFR Part 11 regulations.

You may calibrate the electrode array head using the internal reference resistor. Nothing involving the motor movement happens.

The EVOM™ Auto automated TEER measurement system with the GxP module powered by TotalLab ensures that your data security complies with FDA 21 CFR Part 11 requirements. If you have customized parameters like electrode placement for a plate profile, you may reset all the parameter to their factory default settings. We’ll show you how.

EVOM™ Auto automates TEER measurement, and it is now available with a GxP module to meet the FDA’s 21 CFR Part 11 compliance regulations. Here we will see how to create a new project file in the EVOM™ Auto GxP client software. Two options are available for the GxP software, and creating a project works the same way in both Option A and Option B versions. However, you may only create a project with files in the EVOM™ Auto GXP Option A software. Option B only lets you store EVOM™ Auto data files in the project folder.

EVOM™ Auto with the GxP module lets you perform automated transepithelial electrical (TEER) resistance with confidence that your data security complies with the FDA 21 CFR Part 11 regulations. Here we will see how to run or stop a scheduled measurement sequence.

WPI’s EVOM™ Auto simplifies transepithelial electrical resistance (TEER) measurement by automating measurements in 24- and 96-well plates. A GxP module powered by TotalLab is available to meet the FDA’s 21 CFR Part 11 compliance regulations. Before making measurements, you need to stabilize your electrodes. See how here.

WPI EndOhm chambers are used with WPI's EVOM2 meter for making TEER (transepithelial electrical resistance) measurements. Here Subhra shows the difference between hanging cell culture inserts and standing cell culture inserts.

Sterilization baskets are essential tools in laboratory settings, designed to ensure the safe and efficient sterilization, organization, and transport of instruments, glassware, and small components. WPI sterilization baskets and trays are constructed from stainless steel, so they resist corrosion and withstand high temperatures. A key feature of these baskets is their evenly distributed perforations or mesh design, which allows optimal penetration of sterilizing agents, such as steam, gas (like, ethylene oxide or hydrogen peroxide), or plasma, while promoting proper drainage and drying. Smooth, burr-free edges and surfaces minimize the risk of damage to delicate labware and enhance user safety. Many of our baskets also include silicone mats and grips, to securely hold items during sterilization.

Petri cell culture dishes like WPI’s FluoroDishes™ are commonly used in laboratories, but they require precision and care to ensure the accurate results of your work. Let’s look at several common mistakes made with cell culture dishes and how you can avoid them.

WPI’s EVOM™ line of transepithelial electrical resistance (TEER) measurement systems is the industry standard with thousands of citations in peer-reviewed journals spanning over 40 years. Our newest automated TEER measurement unit, the EVOM™ Auto, works with both 24- and 96-well plates, and now it is available with an optional GxP module to ensure 21 CFR Part 11 compliance to satisfy FDA requirements. In this video you can see how to run, pause, and stop an experiment.

EVOM™ Auto GxP Module is an add-on for the EVOM™ Auto Automated TEER measurement system that ensure 21 CFR Part 11 compliance to satisfy FDA requirements. The EVOM™ Auto is used for making transepithelial electrical resistance (TEER) measurements when you are testing for cell confluency or barrier integrity when you are doing drug absorption studies, tissue engineering, disease model, QC of cell-based assays and more. In this video we will create a sequence to use with an EVOM™ Auto that has the GxP module.

When your transepithelial electrical resistance (TEER) measurement processes require 21 CFR Part 11 compliance to satisfy FDA requirements, WPI’s GxP module for use with the EVOM™ Auto is perfect. Powered by TotalLab, the software database ensured that your EVOM™ Auto TEER data is tracked and stored with appropriate electronic signatures and an extensive audit trail. EVOM™ Auto can be used to perform automated TEER measurement on both 24- and 96-well plates. In this video you can see how to prepare your data for downloading.