EVOM™ GxP compliance Module is 21 CFR Part 11 compliant software that meets the FDA's requirements for electronic records and signatures. It work with the EVOM™ Auto autosampler.  In this video we launch the EVOM™ Auto GxP software from within EVOM™ Auto GxP Client.

SARASOTA, Fla. and PARIS, France, October 14, 2024 -- World Precision Instruments (WPI), a leading provider of high-quality laboratory instruments and equipment for basic research and drug development, and ELVESYS, a leading microfluidic instrument manufacturer specializing in flow control and microfabrication, are excited to announce a global commercial partnership for the distribution of the ELVEFLOW family of products. This distribution partnership aims to broaden WPI's offering in fluidics, continuing to position WPI at the forefront of developing technologies that enable and augment microphysiological systems and organs-on-chip applications. With a strong focus on enabling TEER, fluidics, and other vital technologies in this field, WPI is committed to advancing research and innovation in the life sciences for basic research and drug development.

Transepithelial electrical resistance (TEER) is a methodology that has been used for several decades to measure the resistance across a monolayer of cells to evaluate the barrier function of a cell layer. Historically, TEER measurements were utilized as a basic biological tool as researchers evaluated the permeability of biological layers and the functionality of tight junctions between various cell types. More recently, the utility of TEER measurements has expanded into new and diverse applications in a variety of fields. New applications for TEER measurement that have recently emerged include drug delivery, toxicology, organ-on-chip technology, and quality control of cell therapies. Traditionally used to study the barrier function of epithelial tissues in vitro, TEER has become a versatile and translational tool that has provided valuable insights into the integrity and permeability of complex engineered cell and tissue models as well as quality control measurements for cell-based products.

A new study by Altis Biosystems (Durham, NC) using the EVOM™ Auto is undergoing a peer review prior to publication. It addresses the challenge of predicting gastrointestinal toxicities (GITs) in drug development, which are common adverse events in clinical trials. ​ Traditional animal models fail to accurately replicate human GI physiology, leading to late detection of GITs. ​ Researchers Colleen Pike and James Levi (with their team) developed a high-throughput assay, a 2D human intestinal stem cell-derived model, which assesses cell proliferation, cell abundance, and barrier function to predict clinical diarrhea risk.

See how WPI equipment is being used by researchers to advance organ on a chip (OOC) to improve the outcomes of pregnancies. WPI is working with Dr. Ramkumar Menon, director of UTMB Obstetrics and Gynecology’s Division of Basic Science and Translational Research, who is using Transepithelial Electrical Resistance (TEER) to explore ways to minimize pre-term births.

Surgical forceps are common handheld surgical instruments used for securely grasping and manipulating an object. In a laboratory environment, they may be used for working with tissues, plants, wafers, or small components. In electronics and manufacturing, they can be use when handling circuit boards, jewelry, watch pieces, and much more. Especially in the medical and laboratory realms, the safe handling of surgical forceps is critical for the safety of both the operator and the subject to minimize the chances of infection or injury.

Pulling capillary glass into micropipettes or microelectrodes is a science and an art. Not only must you understand the environmental factors and the physics affecting each pull, but you must also know how to tweak your program to pull tips of consistent shape and size. Glass micropipettes or microelectrodes are used in intracellular recording, patch clamp, microperfusion, and microinjection. Let’s look at some factors that can affect the pulling of glass and how to adjust a program to get the micropipettes you need for your application.

Whether you are performing in-vivo injections for drug delivery calibrated extrusion studies, or any extremely sensitive, low-volume-based application, the quality and performance of your syringe system is paramount. Using a gas-tight syringe is critical for accuracy in various scientific and analytical applications for several reasons. Let’s consider a few instances.

World Precision Instruments is the leading manufacture of benchtop TEER instrumentation including the original equipment manufacturer of Millipore Millicell® ERS-2 (Part number MERS00002) and Millipore Millicell® ERS (Part number MERS00001).

WPI has manufactured TEER instrumentation, including the EVOM2, EVOM3, EVOM™ Manual, and Millicell® ERS-2 (a WPI OEM product), for over three decades. Millipore’s Millicell® ERS 3.0 recently became available and is NOT manufactured by WPI, nor validated or certified to be accurate for TEER measurement. WPI manufactured and validated product, like EVOM™ Manual, the proven gold standard for TEER measurement, ensure the accuracy and reproducibility of your work. Accept no substitutes.

Transepithelial/Endothelial Electrical Resistance (TEER) qualitatively measures cellular monolayer health and quantitatively evaluates cellular confluence by measuring the electrical resistance across a cell monolayer. It is commonly used to assess the integrity and permeability of cellular barriers, such as epithelial and endothelial cell layers in cell culture plates. Organ-on-Chip platforms are an emerging market for TEER applications. Let’s look at what TEER is and how it is used.

The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on 24-well or 96-well high throughput screening (HTS) plates utilizing our innovative EVOM technology, qualitatively measuring cell monolayer health and quantitatively measuring cellular confluence by reaching an increase or a plateau in tissue resistance. The autosampler has a 3-well rinse station for cleaning and stabilizing the electrodes. Now, sterile disposable rinse station inserts are available for your convenience. They fit over the 3-well base rinse station. You can simply throw out the disposable inserts with the solutions when you are changing plates. This short videos shows how easy they are to use.

Each NanoFil needle is individually handcrafted and made for versatility to serve your low-volume sample delivery needs. All needles are made with a universal 26G fixture to support and house each gauge of needle we offer: 33, 34, 35, and even 36G in blunt or beveled styles. WPI currently offers the smallest commercially available needles on the market—perfect for extremely sensitive targets, such as in ophthalmic applications. The universal fixture allows all needles to be used interchangeably across any NanoFil syringe.  Any NanoFil needle can be inserted directly into the barrel of any NanoFil syringe, creating a 1:1 connection with the plunger, resulting in virtually zero dead volume. The sealing gasket seating the needle to the syringe reinforces a tight, uniform fit for a truly gas tight environment. Our design compatibility supports your ever-evolving application needs across varying delivery volumes required. 

Get the highest quality images and video for your research with FluoroDish Cell Culture dishes. Their optical quality glass bottom is as thin as a coverslip, which ensures the least amount of distortions and excellent heat transfer without any of the autofluoresence issues so common with plastic petri dishes.  

Choose the style that suits your application. For live cell imaging, embryo research, and life science researchers working with small sample volumes, the 35mm Fluorodish petri dish with a 10mm well (FD3510) is ideal. Researchers working with expensive chemicals or experimental drugs choose the FD3510. They are also an excellent choice for microinjection applications, because they are designed with the lowest access angle for easier insertion of a micropipette during cellular microinjection. Fluorodishes are also available in 35mm (FD35) or 50mm (FD5040) sizes for cell culturing applications. For better adhesion of neurons, try the 35mm Fluorodish that is coated with poly-D-lysine (FD35PDL).

SARASOTA, Fla. and LYON, France, June 10, 2024 /PRNewswire/ -- World Precision Instruments (WPI), a leading provider of high-quality laboratory instruments and equipment for basic research and drug development, and NETRI, an organs-on-chip industrial start-up, are proud today to announce their partnership. This partnership aims to associate WPI's transepithelial electrical resistance (TEER) technology, and products enabling TEER, with NETRI's proprietary NeoBento organs-on-chip MultiFluidics™ line. WPI has long been at the forefront of developing technologies that enable and augment microphysiological systems and organs-on-chip applications. With a strong focus on enabling TEER, fluidics, and other vital technologies in this field, WPI is committed to advancing research and innovation in the life sciences for basic research and drug development.

Transepithelial Electrical Resistance (TEER) measurements play a vital role in assessing barrier function, tissue integrity, and cell-cell interactions in Organ-on-Chip (OoC) platforms. Measuring TEER by applying a small AC current across a monolayer of cells and measuring the resistance to that current, which provides valuable insights into the physiological relevance and functionality of in vitro models, enabling researchers to study organ-specific responses, disease mechanisms, and drug effects while cells are growing in a controlled microenvironment. This article will explore the applications of TEER in OoC set-ups, critical aspects to TEER measurements in microphysiological systems, and challenges and limitations that must be overcome to fully realize the potential of this technology for OoC platforms.

Tungsten carbide (TC) inserts have revolutionized the field of surgical instrumentation, offering benefits that make them a preferred choice. These inserts, typically made from a combination of tungsten and carbon, exhibit exceptional hardness, strength, and resistance to wear and corrosion, maximizing the lifespan of Surgical scissors, Forceps, and Needle holders.

Protect the investment you have made in surgical instruments and improve the outcomes of your surgeries by regularly inspecting your surgical scissors. Regular inspections ensure that your surgical scissors are in optimal working condition, allowing you to promptly identify and address common issues like dullness, misalignment, or damage. Inspections also help mitigate risks associated with the use of defective or damaged surgical scissors and promotes surgical safety, reducing the likelihood of adverse outcomes. By addressing minor issues early on and following regular cleaning, sterilization, and storage protocols, you can extend the usable lifespan of your surgical instruments, reducing the need for frequent replacements and the associated costs.

Cell therapies have revolutionized the field of regenerative medicine, offering promising treatments for a variety of medical conditions. Maintaining the safety, efficacy, and consistency of cell-based therapies is paramount for their successful application in clinical settings. Quality control measures play a vital role in evaluating the quality of these therapies, from development to administration. This article explores the current approaches to quality control in cell therapies, including the utilization of functional measurement techniques such as transepithelial electrical resistance (TEER), to ensure the quality and safety of these promising treatments.

Cell therapies have emerged as a promising approach for treating various medical conditions, offering the potential for regenerating damaged tissues, restoring normal cellular function, or even acting as cytotoxic cells that target and destroy diseased cells such as cancer cells. As the field of cell-based therapeutics and regenerative medicine continues to advance, ensuring the quality and safety of cell-based therapies is of paramount importance. Quality control measures play a critical role in the manufacturing process of cell therapies, with trans-epithelial electrical resistance (TEER) emerging as a valuable tool for assessing the integrity and functionality of cells used in these therapies. Here, we highlight the use of TEER for quality control of Retinal Pigment Epithelial (RPE) cells, a promising cell therapy for degenerative retinal diseases1.

The use of Disposable biopsy punches has become routine in a variety of industries, from healthcare to forensic science and manufacturing. These small but crucial instruments offer many benefits, ranging from convenience and sterility to cost-effectiveness and reliability.

Disposable biopsy punches are often preferred over reusable biopsy punches because of their convenience and cost-effectiveness. Reusable punches require sterilization between uses, which takes time and resources. Disposable punches streamline your workflow efficiency and enable you to focus your efforts on your results. For high-volume procedures, this can be critical.