WPI Blog

Both Kwik-Sil and Kwik-Cast are silicone adhesives, but they are a little different.

WPI’s EVOM™ line of transepithelial electrical resistance (TEER) measurement systems use silver-silver chloride electrodes for taking measurements. Our newest automated TEER measurement unit, the EVOM™ Auto, is available with an optional GxP module to ensure 21 CFR Part 11 compliance. GxP represents the quality guidelines in place to ensure standards are met. It is used for protocols like Good Laboratory Practice, Good Pharmaceutical Practice, Good Clinical Practice, Good Manufacturing Practice, and Good Research Practice.

Regular maintenance keeps your EVOM™ Auto GxP electrodes performing optimally. Periodically, you will need to re-chloride your electrodes. Just follow the steps shown in this video.

EVOM™ Auto with GxP powered by TotalLab automates your TEER measurements with the confidence that your data security complies with FDA’s 21 CFR Part 11 regulations.

You may calibrate the electrode array head using the internal reference resistor. Nothing involving the motor movement happens.

The EVOM™ Auto automated TEER measurement system with the GxP module powered by TotalLab ensures that your data security complies with FDA 21 CFR Part 11 requirements. If you have customized parameters like electrode placement for a plate profile, you may reset all the parameter to their factory default settings. We’ll show you how.

EVOM™ Auto automates TEER measurement, and it is now available with a GxP module to meet the FDA’s 21 CFR Part 11 compliance regulations. Here we will see how to create a new project file in the EVOM™ Auto GxP client software. Two options are available for the GxP software, and creating a project works the same way in both Option A and Option B versions. However, you may only create a project with files in the EVOM™ Auto GXP Option A software. Option B only lets you store EVOM™ Auto data files in the project folder.

EVOM™ Auto with the GxP module lets you perform automated transepithelial electrical (TEER) resistance with confidence that your data security complies with the FDA 21 CFR Part 11 regulations. Here we will see how to run or stop a scheduled measurement sequence.

WPI’s EVOM™ Auto simplifies transepithelial electrical resistance (TEER) measurement by automating measurements in 24- and 96-well plates. A GxP module powered by TotalLab is available to meet the FDA’s 21 CFR Part 11 compliance regulations. Before making measurements, you need to stabilize your electrodes. See how here.

WPI EndOhm chambers are used with WPI's EVOM2 meter for making TEER (transepithelial electrical resistance) measurements. Here Subhra shows the difference between hanging cell culture inserts and standing cell culture inserts.

Sterilization baskets are essential tools in laboratory settings, designed to ensure the safe and efficient sterilization, organization, and transport of instruments, glassware, and small components. WPI sterilization baskets and trays are constructed from stainless steel, so they resist corrosion and withstand high temperatures. A key feature of these baskets is their evenly distributed perforations or mesh design, which allows optimal penetration of sterilizing agents, such as steam, gas (like, ethylene oxide or hydrogen peroxide), or plasma, while promoting proper drainage and drying. Smooth, burr-free edges and surfaces minimize the risk of damage to delicate labware and enhance user safety. Many of our baskets also include silicone mats and grips, to securely hold items during sterilization.

Petri cell culture dishes like WPI’s FluoroDishes™ are commonly used in laboratories, but they require precision and care to ensure the accurate results of your work. Let’s look at several common mistakes made with cell culture dishes and how you can avoid them.

WPI’s EVOM™ line of transepithelial electrical resistance (TEER) measurement systems is the industry standard with thousands of citations in peer-reviewed journals spanning over 40 years. Our newest automated TEER measurement unit, the EVOM™ Auto, works with both 24- and 96-well plates, and now it is available with an optional GxP module to ensure 21 CFR Part 11 compliance to satisfy FDA requirements. In this video you can see how to run, pause, and stop an experiment.

EVOM™ Auto GxP Module is an add-on for the EVOM™ Auto Automated TEER measurement system that ensure 21 CFR Part 11 compliance to satisfy FDA requirements. The EVOM™ Auto is used for making transepithelial electrical resistance (TEER) measurements when you are testing for cell confluency or barrier integrity when you are doing drug absorption studies, tissue engineering, disease model, QC of cell-based assays and more. In this video we will create a sequence to use with an EVOM™ Auto that has the GxP module.

When your transepithelial electrical resistance (TEER) measurement processes require 21 CFR Part 11 compliance to satisfy FDA requirements, WPI’s GxP module for use with the EVOM™ Auto is perfect. Powered by TotalLab, the software database ensured that your EVOM™ Auto TEER data is tracked and stored with appropriate electronic signatures and an extensive audit trail. EVOM™ Auto can be used to perform automated TEER measurement on both 24- and 96-well plates. In this video you can see how to prepare your data for downloading.

EVOM™ GxP compliance Module is 21 CFR Part 11 compliant software that meets the FDA's requirements for electronic records and signatures. It work with the EVOM™ Auto autosampler.  In this video we launch the EVOM™ Auto GxP software from within EVOM™ Auto GxP Client.

SARASOTA, Fla. and PARIS, France, October 14, 2024 -- World Precision Instruments (WPI), a leading provider of high-quality laboratory instruments and equipment for basic research and drug development, and ELVESYS, a leading microfluidic instrument manufacturer specializing in flow control and microfabrication, are excited to announce a global commercial partnership for the distribution of the ELVEFLOW family of products. This distribution partnership aims to broaden WPI's offering in fluidics, continuing to position WPI at the forefront of developing technologies that enable and augment microphysiological systems and organs-on-chip applications. With a strong focus on enabling TEER, fluidics, and other vital technologies in this field, WPI is committed to advancing research and innovation in the life sciences for basic research and drug development.

Transepithelial electrical resistance (TEER) is a methodology that has been used for several decades to measure the resistance across a monolayer of cells to evaluate the barrier function of a cell layer. Historically, TEER measurements were utilized as a basic biological tool as researchers evaluated the permeability of biological layers and the functionality of tight junctions between various cell types. More recently, the utility of TEER measurements has expanded into new and diverse applications in a variety of fields. New applications for TEER measurement that have recently emerged include drug delivery, toxicology, organ-on-chip technology, and quality control of cell therapies. Traditionally used to study the barrier function of epithelial tissues in vitro, TEER has become a versatile and translational tool that has provided valuable insights into the integrity and permeability of complex engineered cell and tissue models as well as quality control measurements for cell-based products.

A new study by Altis Biosystems (Durham, NC) using the EVOM™ Auto is undergoing a peer review prior to publication. It addresses the challenge of predicting gastrointestinal toxicities (GITs) in drug development, which are common adverse events in clinical trials. ​ Traditional animal models fail to accurately replicate human GI physiology, leading to late detection of GITs. ​ Researchers Colleen Pike and James Levi (with their team) developed a high-throughput assay, a 2D human intestinal stem cell-derived model, which assesses cell proliferation, cell abundance, and barrier function to predict clinical diarrhea risk.

See how WPI equipment is being used by researchers to advance organ on a chip (OOC) to improve the outcomes of pregnancies. WPI is working with Dr. Ramkumar Menon, director of UTMB Obstetrics and Gynecology’s Division of Basic Science and Translational Research, who is using Transepithelial Electrical Resistance (TEER) to explore ways to minimize pre-term births.

Surgical forceps are common handheld surgical instruments used for securely grasping and manipulating an object. In a laboratory environment, they may be used for working with tissues, plants, wafers, or small components. In electronics and manufacturing, they can be use when handling circuit boards, jewelry, watch pieces, and much more. Especially in the medical and laboratory realms, the safe handling of surgical forceps is critical for the safety of both the operator and the subject to minimize the chances of infection or injury.

Pulling capillary glass into micropipettes or microelectrodes is a science and an art. Not only must you understand the environmental factors and the physics affecting each pull, but you must also know how to tweak your program to pull tips of consistent shape and size. Glass micropipettes or microelectrodes are used in intracellular recording, patch clamp, microperfusion, and microinjection. Let’s look at some factors that can affect the pulling of glass and how to adjust a program to get the micropipettes you need for your application.

Whether you are performing in-vivo injections for drug delivery calibrated extrusion studies, or any extremely sensitive, low-volume-based application, the quality and performance of your syringe system is paramount. Using a gas-tight syringe is critical for accuracy in various scientific and analytical applications for several reasons. Let’s consider a few instances.