In 2022, the United States Food and Drug Administration (FDA) approved 37 new drugs, of which 20 were chemical entities and 17 were biologics. In 2023, drug discovery remains strong with many new advancements a result of changing landscapes in both the types of drugs that are being developed and the new and innovative assay that are being launched to evaluate drugs preclinically. Therapeutic development is still highly focused on diseases that affect large populations of people for which there are lack of effective treatments, with 2023’s most anticipated drug launches expected to be in areas of cancer, Alzheimer’s disease, cardiovascular disease, and ulcerative colitis.

When it comes to sterilizing lab forceps, it is crucial to follow proper protocols to maintain a sterile environment and prevent cross-contamination. Like other surgical instruments, laboratory forceps may be sterilized by autoclaving, dry heat, or a chemical sterilant. However, forceps are uniquely designed for many specific functions, and a few pointers here can ensure you get the best results.

NOTE: Always follow the manufacturer's instructions and best practices to ensure effective sterilization and maintenance of your lab forceps.

In any laboratory, having key lab supplies is almost as important as having the major equipment. Choosing a reputable supplier of these necessary supplies is as important as having quality laboratory supplies when you need them. WPI wants to be your partner in early drug discovery, and we stock a wide variety of lab supplies, many of which can ship the same business day. Having a variety of lab supplies ready to ship makes us a dependable research partner. Here are some of the popular supplies that we keep on hand to meet your needs for your upcoming experiment

In 2022, the United States Food and Drug Administration (FDA) approved 37 new drugs, of which 20 were chemical entities and 17 were biologics. In 2023, drug discovery remains strong with many new advancements a result of changing landscapes in both the types of drugs that are being developed and the new and innovative assay that are being launched to evaluate drugs preclinically. Therapeutic development is still highly focused on diseases that affect large populations of people for which there are lack of effective treatments, with 2023’s most anticipated drug launches expected to be in areas of cancer, Alzheimer’s disease, cardiovascular disease, and ulcerative colitis.

Hemostatic forceps, hemostats, are used primarily to control bleeding during surgical procedures, and they are also used for a variety of other applications. Most hemostatic forceps have ring handles and a ratchet-style, locking mechanism to adjust the tension on the forceps and to keep the jaws clamped in place, maintaining constant pressure on the tissue or blood vessel being occluded. They also have jaws with interlocking serrations or teeth for a secure grip on tissues. The tips of hemostats are often narrow and delicate, allowing for precise manipulation of tissues and vessels. They vary in size, tip shape, type of metal, and function. Here are some applications for which hemostatic forceps are uniquely designed.

This article shows you how to appropriately care for your surgical insturments to ensure long lasting, highly functioning tools for your application.

One of the most common surgical instruments in a laboratory is lab forceps or tweezers. Thumb forceps used in a lab come in various lengths, and the tips can be straight, curved, angled, or angled on the side. They can be made of stainless steel, German steel, Dumoxel, Dumastar, or titanium. They can have smooth tips, serrated tips, or teeth. They are even available with tungsten carbide inserts. Each style has its own purpose.

In a life science laboratory, quality surgical scissors are indispensable for dissection, suturing, small animal surgeries, tissue preparation, and more. The variety of surgical scissors can be overwhelming. To help you choose which surgical scissors are right for your application, let’s look at some of our most popular ring handled surgical scissors and their intended uses.

If the EVOM™ Auto software switches from Resistance to TEER mode while you are selecting menu options, here's a quick tip:

Be careful when selecting Resistance mode, do not tap the background window and do not click on the side arrows.

Tapping the background window will switch you to TEER mode.

Instead, tap an option on the forefront square window to stay in Resistance mode.

The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.

The video below shows you how to schedule an operation on the EVOM™ Auto:

The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.

The video below shows you how to stabilize the electrode array on the EVOM™ Auto:

The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.

The video below shows you how to download and how to delete a data file EVOM™ Auto:

The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.

The video below shows details the features and functions of the Experiment window on the EVOM™ Auto:

The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.

The video below shows you the features of the homepage on the EVOM™ Auto:

In vitro models have employed two common methods to quantify changes in endothelial barrier integrity: transepithelial/transendothelial electrical resistance (TEER) and tracer compound permeability.1  TEER is a non-invasive method that quantifies changes in electrical conductance to measure confluency and barrier integrity. Tracer compound permeability uses molecules of defined molecular weights to measure the size exclusion capacity of cell barriers (e.g., 4 kDa FITC-dextran or FD4).1  Using the EVOM™ Manual (EVOM-MT-03-01) with the EndOhm TEER electrode and cell culture permeable supports, this application note describes how to non-invasively evaluate endothelial barrier integrity after cytokine treatment and provides a method to identify vasoactive compounds that have the potential to induce vascular injury.  Tracer compound permeability studies are combined with TEER evaluation to elucidate treatment-induced impacts on both intercellular junctions and paracellular transport (Fig. 1).

World Precision Instruments' (WPI) legacy Robotic Epithelial Measurement System (REMS) and the new advanced, upgraded version of REMS, EVOM™ Auto, are high-throughput, automated transepithelial/transendothelial electrical resistance (TEER) measurement systems. These robotic systems, combined with EVOM™ technology, expedite TEER measurements.

In the process of ‘cell cycle’, cells grow and divide into two genetically identical daughter cells. It is regulated by a complex signaling pathway which keeps cell homeostasis by regulating cell division and DNA duplication1. On the other hand, because cancer cells grow and divide indefinitely out of cell cycle control, anti-mitotic drugs are used to suppress abnormal proliferation of cancer cells2. In particular, Nocodazole is known to be a representative anti-mitotic drug for cancer treatment, and it has the characteristics of disturbing microtubule dynamics during cytoplasmic and nuclear division3,4.

Have you got the new EVOM Auto TEER Measurement System for 96-well HTS plates? This short videos shows how easy it is to setup.