Microfluidic Bubble Detector

$1,266
$1,266

505871

$1,266
$1,266
Size

Prices valid in USA, Canada, and PR only.

Optical microfluidic detector of fluid interfaces

Liquid interface detection

  • Detection based on true/false logic

Bubble detection

  • Detect and avoid bubbles before affect your study

Details

Options

Order code Description
505871 Microfluidic Bubble Detector, Large
505872 Microfluidic Bubble Detector, Small

The most-popular application for the Inline Liquid Sensor is to use the sensor as a microfluidic bubble detector. Bubbles are a big challenge to address in microfluidics, as they can induce flow modifications or interact with the experiment and damage to the sample. Users can monitor and count the passage of microfluidic bubbles at any given point of their setup and automate the experiment accordingly.

For example, when paired with an OB1 MK3+ it is possible to increase the pressure or switch a valve to direct the bubbles into another fluidic path.

Benefits

  • Reliable non invasive technique
  • Cost effective compared to camera check
  • Based on true/false logic
  • Large compatibility: wide range of tubing size
  • Use anywhere in your setup
  • Prevents damage in cells with bubble bursts
  • Setup automation: it is possible to trigger fluid control operations based on the bubble detection signal

The Inline Fluid Sensor can be plugged directly onto Elveflow’s OB1 MK3+, or it can be used as a standalone unit with the Sensor Reader.

 

Applications

Example: Bilateral Medium Recirculation

Based on the liquid detection principle, you can perform Medium recirculation without any recirculating valve, using the Inline optical sensor, the OB1 Mk3+ flow controller and our powerful scheduler using the all-in-one ESI software. Next, we will show you a smart and easy way to perform bidirectional recirculation without using valves.

Schema LiquidSensor

Materials:

  • Pressure source
  • Elveflow® pressure & flow control instrument (OB1 MK3+)
  • Sample reservoirs and tubing (a small reservoir, medium reservoir or a large microfluidic reservoir), one for each medium sample
  • Microfluidic chip (here an organ on a chip microfluidic chip from Aline Inc…)

Procedure:

Using the Elveflow scheduler (see below figure), you can easily automate your setup by using elementary steps like applying a pressure profile, taking conditional actions and detecting bubbles. We present here the experimental protocol with the corresponding scheduler steps.

  • Apply pressure on line 1: STEP 1.
  • When tube 1 is empty, bubbles will appear.
  • The liquid sensor 1 detects the bubbles and then pressure in line 1 is turned off. Simultaneously a pressure is applied in line 2 => STEP 3 & 4
  • Then, when the tube 2 is empty, bubbles will appear.
  • The liquid sensor 2 detects the bubbles and the pressure in line 2 is turned off. Simultaneously, a pressure is applied in line 1 => STEP 6 & 7
  • The experiment can be continued as many times as you want.

 Bilateral Medium Recirculation ESI_Config

Specifications

Principle of operation

The Inline Fluid Sensor detection principle is based on the measurement of the optical path and the variation of this path when the flowing medium is changing.

A light beam is emitted by a LED of known power. This light beam goes through the capillary and the fluid flowing through. It is then collected by an NPN silicon phototransistor which converts the light power into an electrical signal. When a the fluid changes, the optical index and the light absorption coefficient change accordingly. It induces a change in the electrical power and allows detection of changes in the fluid.

MBD Bubble detector sketch
Microfluidic Bubble Detector

$1,266.00