Front Filling Nanofil Syringe

WPI’s NanoFil™ is a gas-tight microliter injection system for small-animal research that supports needles down to 36 gauge. Its ultra-low dead volume enables direct sub-microliter injections without oil backfilling, and a patented silicone gasket allows quick needle switching with minimal sample loss. Compatible with GC/CE capillaries and various tubing, it offers blunt and unique 25° tri-surface beveled needles (26–36G) that reduce tissue damage and improve durability. The system is widely used for precise tissue injections, including ophthalmic applications, and is supported by application kits and peer-reviewed studies.

Each NanoFil needle is individually handcrafted and made for versatility to serve your low-volume sample delivery needs. All needles are made with a universal 26G fixture to support and house each gauge of needle we offer: 33, 34, 35, and even 36G in blunt or beveled styles. WPI currently offers the smallest commercially available needles on the market—perfect for extremely sensitive targets, such as in ophthalmic applications. The universal fixture allows all needles to be used interchangeably across any NanoFil syringe.  Any NanoFil needle can be inserted directly into the barrel of any NanoFil syringe, creating a 1:1 connection with the plunger, resulting in virtually zero dead volume. The sealing gasket seating the needle to the syringe reinforces a tight, uniform fit for a truly gas tight environment. Our design compatibility supports your ever-evolving application needs across varying delivery volumes required.