A fourth peer-reviewed publication featuring the EVOM™ Auto was published this month in Toxicology in Vitro. Led by scientists at Johnson & Johnson in Belgium and Pennsylvania, the study used automated TEER to evaluate human colonoid-derived monolayers (hCDMs) against conventional Caco-2 monolayers for drug accumulation, toxicity, and pharmacodynamics research. Automated TEER supported high-throughput barrier integrity monitoring, confirmed model readiness during differentiation, and revealed mechanistic toxicity insights tied to barrier disruption. The study found hCDMs maintain a physiological barrier of 332 Ω·cm² and respond to toxicants more like clinical models than Caco-2 does, strengthening the case for organoid-based in vitro toxicology.

Mosquito and Kelly hemostats are locking hemostatic forceps designed to clamp vessels and securely grasp tissue, but their size and jaw designs suit different applications. Mosquito forceps feature small, fine jaws that provide greater precision when working with small vessels, delicate tissue, and confined spaces. Kelly forceps are larger, with greater jaw capacity for medium-sized vessels and heavier tissue. Their serrations also differ: Kelly forceps have transverse serrations on approximately the distal half of the jaws. Learn how size, jaw design, serration pattern, working space, and material can help you select the right hemostatic forceps for your application.

La nouvelle seringue NanoFil™ 5 µL de WPI est conçue pour les chercheurs qui exigent une précision exceptionnelle lors de l'administration de volumes ultra-faibles dans les applications ophtalmiques et en neurosciences. Dotée d'un design étanche aux gaz, sans volume mort, et d'un format compact favorisant une utilisation confortable à une main, cette seringue améliore la précision du dosage, la résolution du volume et la conservation des réactifs. Les chercheurs peuvent ainsi garder un meilleur contrôle lors de procédures délicates telles que les injections intravitréennes, sous-rétiniennes et stéréotaxiques, tout en minimisant les perturbations tissulaires et en réduisant la fatigue de l'opérateur. Idéale pour la thérapie génique, l'optogénétique, la recherche CRISPR et l'administration de médicaments oculaires, la seringue NanoFil™ 5 µL contribue à obtenir des résultats expérimentaux fiables et reproductibles.

Choosing the right hemostat involves more than selecting the correct size. Jaw design influences how an instrument grips tissue, distributes pressure, and minimizes trauma during surgical procedures. This article compares the most common hemostat jaw patterns, including fine transverse serrations, partial and full-length serrations, and Rochester-Carmalt grooves, explaining when each design is most appropriate. You will learn how jaw geometry affects grip strength, tissue control, and vessel occlusion, and how matching the instrument to the procedure can improve surgical consistency, reduce tissue damage, and support more reproducible research outcomes.

Researchers often compare serrated and smooth jaws as though they are two versions of the same instrument. In reality, they represent two different instrument families. Serrated jaws are the standard on ratcheted hemostatic forceps because they provide the secure grip needed for reliable hemostasis. Smooth jaws are typically found on vascular and bulldog clamps designed for temporary, atraumatic vessel occlusion. This article explains why these designs exist, how they distribute force differently, and how selecting the appropriate instrument category has a greater impact on tissue preservation than jaw pattern alone.

Once you understand how a hemostat works, it's much easier to recognize the difference between a high-quality instrument and one built to a lower standard. Reliable performance depends on three critical elements working together: a precision box lock that keeps the jaws aligned, a finely machined ratchet that delivers secure, repeatable clamping force, and properly tempered stainless steel that provides consistent spring tension over years of use.

Reproducibility failures in biomedical research are often attributed to statistics, sample sizes, or reporting gaps, but instrument standardization is a controllable variable that rarely gets examined. This article argues that microsurgical instruments reduce technique-dependent variation through tighter tip tolerances, spring-balanced shanks, and calibrated ratchet mechanisms, making surgical outcomes more consistent across operators and subjects. It covers how instrument-mediated tissue trauma introduces noise into experimental data, why maintenance is a reproducibility practice, and how specifying instruments in methods sections supports replication and peer review.