NEWS: EVOM Technology Used with 96-Well Human Gut Organoid-Derived Monolayer System
Capturing Multiple Quantitative Pathway Readouts
Nature recently published a paper from researchers at Merck (Wright, Li, Shafer, et al.) who used WPI's EVOM™ technology to examine disruptions in the gut epithelial barrier can lead to issues like infammatory bowel disease (IBD). Using human primary gut organoids grown as monolayers, they were able to quantify the barrier function and other key factors. Their novel 96-well human gut organoid-derived monolayer system enables quantitative assessment of possible drug therapies. According to their article, "This system is well suited to provide pivotal functional data to support translational target and drug discovery efforts."
WPI was the pioneer in the field of TEER measurement, introducing the first TEER meter over 40 years ago. Today we offer a line of TEER meters, including the EVOM™ Auto for automated measurements in 24 and 96 Transwell plates and the EVOM™ Manual for manual TEER measurement. We also have a variety of electrodes for many applications.
Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts. Charles W. Wright, Naomi Li, et al. Scientific Reports 2023 13:1, 13, 1, 9 2023.
