A fourth peer-reviewed publication featuring the EVOM™ Auto was published this month in Toxicology in Vitro. Led by scientists at Johnson & Johnson in Belgium and Pennsylvania, the study used automated TEER to evaluate human colonoid-derived monolayers (hCDMs) against conventional Caco-2 monolayers for drug accumulation, toxicity, and pharmacodynamics research. Automated TEER supported high-throughput barrier integrity monitoring, confirmed model readiness during differentiation, and revealed mechanistic toxicity insights tied to barrier disruption. The study found hCDMs maintain a physiological barrier of 332 Ω·cm² and respond to toxicants more like clinical models than Caco-2 does, strengthening the case for organoid-based in vitro toxicology.

Mosquito and Kelly hemostats are locking hemostatic forceps designed to clamp vessels and securely grasp tissue, but their size and jaw designs suit different applications. Mosquito forceps feature small, fine jaws that provide greater precision when working with small vessels, delicate tissue, and confined spaces. Kelly forceps are larger, with greater jaw capacity for medium-sized vessels and heavier tissue. Their serrations also differ: Kelly forceps have transverse serrations on approximately the distal half of the jaws. Learn how size, jaw design, serration pattern, working space, and material can help you select the right hemostatic forceps for your application.

WPI’s new 5 µL NanoFil™ syringe is designed for researchers who require exceptional precision when delivering ultra-low volumes in ophthalmic and neuroscience applications. Featuring a gas-tight, zero-dead-volume design and a compact format that supports comfortable single-handed operation, the syringe improves dosing accuracy, volume resolution, and reagent conservation. Researchers can maintain greater control during delicate procedures such as intravitreal, subretinal, and stereotaxic injections while minimizing tissue disruption and reducing operator fatigue. Ideal for gene therapy, optogenetics, CRISPR research, and ocular drug delivery, the 5 µL NanoFil™ syringe helps produce reliable, reproducible experimental results.

Choosing the right hemostat involves more than selecting the correct size. Jaw design influences how an instrument grips tissue, distributes pressure, and minimizes trauma during surgical procedures. This article compares the most common hemostat jaw patterns, including fine transverse serrations, partial and full-length serrations, and Rochester-Carmalt grooves, explaining when each design is most appropriate. You will learn how jaw geometry affects grip strength, tissue control, and vessel occlusion, and how matching the instrument to the procedure can improve surgical consistency, reduce tissue damage, and support more reproducible research outcomes.

Researchers often compare serrated and smooth jaws as though they are two versions of the same instrument. In reality, they represent two different instrument families. Serrated jaws are the standard on ratcheted hemostatic forceps because they provide the secure grip needed for reliable hemostasis. Smooth jaws are typically found on vascular and bulldog clamps designed for temporary, atraumatic vessel occlusion. This article explains why these designs exist, how they distribute force differently, and how selecting the appropriate instrument category has a greater impact on tissue preservation than jaw pattern alone.

Once you understand how a hemostat works, it's much easier to recognize the difference between a high-quality instrument and one built to a lower standard. Reliable performance depends on three critical elements working together: a precision box lock that keeps the jaws aligned, a finely machined ratchet that delivers secure, repeatable clamping force, and properly tempered stainless steel that provides consistent spring tension over years of use.

Reproducibility failures in biomedical research are often attributed to statistics, sample sizes, or reporting gaps, but instrument standardization is a controllable variable that rarely gets examined. This article argues that microsurgical instruments reduce technique-dependent variation through tighter tip tolerances, spring-balanced shanks, and calibrated ratchet mechanisms, making surgical outcomes more consistent across operators and subjects. It covers how instrument-mediated tissue trauma introduces noise into experimental data, why maintenance is a reproducibility practice, and how specifying instruments in methods sections supports replication and peer review. 

Selecting the right surgical instrument involves more than choosing the correct type. It also means choosing the right tip geometry. Features such as straight or curved profiles, fine or broad tips, serrated or smooth surfaces, and angled designs all influence how an instrument interacts with tissue. These design characteristics affect precision, visibility, force distribution, and tissue handling, making them essential considerations in microsurgery, small animal research, and other delicate procedures. This article explains why different tip geometries exist and how understanding their purpose can help researchers minimize tissue trauma, improve surgical control, and achieve more consistent experimental outcomes.