Strumenti di precisione per il mondo

Pulling a clean glass micropipette tip depends on more than getting the settings right once. Heat, force, distance, and delay each shape the taper differently, but centering the glass in the filament matters just as much, since radiant heat drives most of the pull. Room temperature, humidity, glass batch, and filament wear can all shift results even when the program has not changed. This guide breaks down each setting, explains why a misshapen tip and a broken tip call for different fixes, and offers a troubleshooting checklist for the most common pulling problems, plus tips for keeping results consistent over time.

Barrier-forming tissues such as vascular endothelium and the BBB tightly regulate molecular exchange and tissue homeostasis, making their integrity  a central readout in disease modeling, drug discovery, and toxicity testing. TEER is a widely adopted,  non-invasive method for quantifying barrier formation and detecting barrier disruption. The EVOM™ Chip platform integrates embedded electrodes into microphysiological system formats to deliver  sensitive, reproducible TEER measurements, eliminating manual variability and enabling continuous, hands-free monitoring. EVOM™ Chip delivers real-time, high-fidelity insights into cellular barrier dynamics while establishing a standardized approach for TEER measurement.

Stainless steel is the foundation of most surgical instruments, but not all stainless steel is created equal. Different alloy grades offer different levels of corrosion resistance, hardness, strength, and durability. This article explains what makes stainless steel “stainless,” how chromium, carbon, nickel, and molybdenum affect performance, and why 300 and 400 series steels are commonly used for surgical instruments. It also compares common stainless steel grades and explains how material quality, heat treatment, and finishing influence instrument life. Understanding the steel behind an instrument can help researchers evaluate quality, durability, maintenance requirements, and long-term value.

Tungsten carbide inserts can significantly extend the working life of a hemostat by providing an exceptionally hard, wear-resistant gripping surface. Unlike standard stainless steel jaws, carbide inserts resist wear and help maintain their intended gripping geometry through repeated use. This can contribute to more consistent instrument performance and reduce the need to compensate for worn jaws with additional clamping force. For frequently used instruments, the longer service life can also offset the higher initial cost. Learn how tungsten carbide inserts work, why jaw hardness matters, and when upgrading from a standard stainless steel hemostat may make sense for research applications.

Discoloration on a stainless steel instrument does not necessarily mean it is rusting. Surface stains can result from cleaning chemistry, water droplets, excessive heat, contact with ammonia, mixed metals, or even dried blood and biological debris. This guide explains how stain color can provide clues to the cause and introduces a simple pencil eraser test to help distinguish staining from actual corrosion. If the discoloration is removed and the steel underneath remains smooth, it is likely a stain. If pitting or permanent surface damage is revealed, corrosion has occurred and the instrument may need to be removed from service.

Routine inspection helps ensure tweezers continue to deliver the precision required for fine dissection, tissue handling, and micromanipulation. This step-by-step QC guide covers three critical areas: tip alignment, instrument surface, and spring tension. Learn how to identify gaps, crossing or damaged tips, corrosion, pitting, burrs, and signs of metal fatigue before they affect performance. The guide also provides clear pass/fail criteria and recommendations for how often precision and general-purpose tweezers should be inspected. A quick check can reveal problems that are difficult to see during normal use and help determine when an instrument should be replaced.

A fourth peer-reviewed publication featuring the EVOM™ Auto was published this month in Toxicology in Vitro. Led by scientists at Johnson & Johnson in Belgium and Pennsylvania, the study used automated TEER to evaluate human colonoid-derived monolayers (hCDMs) against conventional Caco-2 monolayers for drug accumulation, toxicity, and pharmacodynamics research. Automated TEER supported high-throughput barrier integrity monitoring, confirmed model readiness during differentiation, and revealed mechanistic toxicity insights tied to barrier disruption. The study found hCDMs maintain a physiological barrier of 332 Ω·cm² and respond to toxicants more like clinical models than Caco-2 does, strengthening the case for organoid-based in vitro toxicology.